The Role of Hyaluronic Acid Versus Platelet-Rich Plasma in Treating Osteoarthritis

A Prospective, Double-Blind Randomized Controlled Trial Comparing Clinical Outcomes and Effects on Intraarticular Biology for the Treatment of Knee Osteoarthritis

By: Brian J. Cole, MD, MBA, Vasili Karas, MD, MS, Kristen Hussey, MS, Kyle Pilz, MMS, PA-C, and Lisa A. Fortier, DVM, PhD, DACVS Investigation performed at the Rush University Medical Center, Chicago, Illinois

Purpose: To compare the clinical and biological effects of an intra-articular injection of PRP with those of an intra-articular injection of HA in patients with mild to moderate knee OA. Interview originally published in the American Journal of Sports Medicine as a February Podcast.

bcmdThe use of plateletrich plasma (PRP) for the treatment of osteoarthritis (OA) has demonstrated mixed clinical outcomes in randomized controlled trials when compared with hyaluronic acid(HA), an accepted nonsurgical treatment for symptomatic OA. Biological analysis of PRP has demonstrated an anti-inflammatory effect on the intra-articular environment.

We found no difference between HA and PRP at any time point in the primary outcome measure: the patient-reported WOMAC pain score. Significant improvements were seen in other patient-reported outcome measures, with results favoring PRP over HA. Preceding a significant difference in subjective outcomes favoring PRP, there was a trend toward a decrease in 2 proinflammatory cytokines, which suggest that the anti-inflammatory properties of PRP may contribute to an improvement of symptoms.

Click here to read the article.

Discover Your Health with Biostrap; Stem Cell Therapy: Myths and Misconceptions; Advancements in Pediatric Orthopedics-Sports Medicine

Episode 16.36 with Hosts Steve Kashul and Dr. Brian Cole. Broadcasting on ESPN Chicago 1000 WMVP-AM Radio, Saturdays from 8:30 to 9:00 AM/c.

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Segment One: Sameer Sontakey, founder of Biostrap discusses the launching of Biostrap Wristband and ShoeclipBiostap with its advanced technology as a full body health tracking platform. Most wearables utilize a very basic PPG sensor capable of capturing your heart rate during moderate activity. Their signal, however is completely binary – counting only that a beat occurred. Our system is different – instead of checking your pulse at all times, we check while you’re still, allowing us to capture high-fidelity, raw PPG waveforms.

These waveforms are the same kind that your doctor uses to evaluate your heart’s health. That’s why our device is being utilized by doctors and clinicians to monitor their patients. Our clinical-grade PPG sensor allows us to gather extremely precise heartbeat data. Biostrap captures over 2,000 heartbeats every 24 hours. Every single beat is analyzed for 29 different parameters, then analyzed against all of your other heartbeats from the last 24 hours.

Related: Discover Your Health with Biostrap | Heart Rate Variability: Sync Up with Your Body


Segment Two: Dr. Cole discusses stem cell therapy and its use for elite athletes andstem-cell
the weekend warrior; definition, benefits, myths and misconceptions; the procedure and current research.

Manipulating stem cells from a patient’s bone marrow near the site of the defect in order to encourage cartilage growth and regeneration is an approach that could potentially be used to avoid surgical intervention.

Ongoing clinical trials and research efforts


Segment Three: Dr. John Polousky from Children’s Health in Dallas discusses the challenges of the orthopedic treatment and sports medicine in pediatric patients; new advancements in pediatric orthopedics; use of donated tissue in helping patients to heal and currently active research to help future patients.

Dr. John Polousky is a board-certified orthopedic surgeon who is certified in the subspecialty of sports medicine. He is fellowship-trained in pediatric orthopedics and has completed further post-residency training in orthopedic sports medicine.

Dr. Polousky earned his medical degree from the University of Southern California and completed a residency in orthopedic surgery at The Cleveland Clinic Foundation. He then completed a pediatric orthopedic surgery fellowship at The Children’s Hospital Colorado, a pediatric orthopedic surgery mini-fellowship in limb deformity surgery at the International Center for Limb Lengthening at Baltimore’s Sinai Hospital and additional training in orthopedic sports medicine at the University of Colorado.

Dr. Polousky is a former Division I collegiate athlete. He was a four-year letter winner, Allo_ESPN_logo-banner_300x250_04-16two-time academic all-conference and honorable mention all-conference center at Colorado State University. Dr. Polousky is actively involved in research. He has published numerous articles and book chapters on topics in pediatric orthopedics and sports medicine. He currently serves on the Executive Committee of the Osteochondritis Dissecans Study Group of North America and is the chairman of the Membership Committee of that organization.

New Openings: Barry’s Boot Camp & True Food Kitchen; Optons for Weight Loss

Episode 16.35 with Hosts Steve Kashul and Dr. Brian Cole. Broadcasting on ESPN Chicago 1000 WMVP-AM Radio, Saturdays from 8:30 to 9:00 AM/c.

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Segment One: Joey Gonzalez CEO of Barry’s Boot Camp in Chicago discusses the opening of their new Chicago Location.

Since 1998, Barry’s Bootcamp has been delivering The Best Workout in the World®  to a legendary following, including A-list celebs, models—even Olympic athletes. Our signature hour-long workouts include 25-30 minutes of interval cardiovascular treadmill routines and 25-30 minutes of strength training utilizing free weights, resistance bands, medicine balls and other equipment. Instructors, muscle groups and even workout segments vary throughout the week so that no one class is ever the same.

Our innovative technique works to “shock” the body in the most efficient and effectivebarrys-logo way to improve your cardiovascular system, lose weight and build muscle. Our world-class instructors are the best in the business and promote a positive, supportive environment that will help you break past your own personal boundaries. Regardless of skill level, you can burn 1,000 calories in just one hour. You will see and feel results right away in a thumping music-filled environment where every class feels new, fun and exciting.


Segment Two: Karen Malkin from Karen Malkin Health Counceling discusses Dr. Andrew Weil’s True Food Kitchen. All True Food Kitchen locations feature dishes that closely adhere to the principles of Dr. Weil’s anti-inflammatory diet. They are intended to be a new kind of restaurant: one in which delicious flavors, healthy nutrients, environmental awareness and an inviting atmosphere come together to create an unforgettable dining experience.

Dishes are influenced by Mediterranean, Asian and Californian cuisine, and include soups, appetizers, salads, pasta, rice and noodle dishes, wood grilled dishes, sandwiches and burgers, brick oven pizzas and desserts.

Karen Malkin-Karen Malkin Health Counseling

Sample dishes: Wild Smoked Salmon with Shaved Radishes; Lemon Cream & Wasabi Peas; Sashimi Tuna Salad with Avocado, Cucumber, Tomato, Edamame & Ginger; Curry Chicken with Rice Noodles; Tuscan Kale Salad; Cauliflower & Cashews; Herbed Hummus; Green Tea Soba Noodles with Peas; Bok Choy & Lemongrass; Fresh Tomato Pizza with Pasilla Chile & Manchego; Grilled Wild Ahi Sliders with Wasabi, Radishes and Cucumber on Pumpernickel; and Natural Half Chicken with Farro, Walnuts, Dried Fig, Brussels Sprouts & Squash.


Segment Three: Dr. Alfonso Torquoti from Rush University Medical Center discusses options for the treatment of obesity including Bariatric Surgery. Bariatric surgery, also called weight loss surgery, helps severely obese people lose weight. In doing so, it also helps prevent or improve obesity-related conditions such as diabetes and high blood pressure. During a bariatric procedure, a surgeon removes or blocks off part of your stomach. This leaves you feeling fuller sooner and reduces your desire to eat. Some types of bariatric surgery also limit your body’s absorption of calories from food.

Bariatric surgery is an effective way to lose weight and reduce the risk of obesity-related health problems. It might be a good choice for you if these statements are true:

  • You are morbidly obese. This means you have a BMI, or body mass index, of at least 40, or a BMI of at least 35 plus an obesity-related disease such as diabetes or high blood pressure. Determine your BMI.
  • You have tried to lose weight using other methods and they have not worked.
  • You are committed to making the changes necessary for long-term success. Surgery is only the beginning of the weight-loss journey. To lose weight and keep it off — which most bariatric surgery patients are able to do — you will have to commit to making healthy choices.

Reward Yourself at CEO Challenges; Complex Knee Injuries in Pro Athletes; NBA vs NFL Injuries

Episode 16.34 with Hosts Steve Kashul and Dr. Brian Cole. Broadcasting on ESPN Chicago 1000 WMVP-AM Radio, Saturdays from 8:30 to 9:00 AM/c.

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Segment One:  The President of CEO Challenges, Ted Kennedy talks about the Camaraderie, Experience & Opportunity provided by CEO Challenges. Meet and compete with fellow C-suite executives that share your passion and interests. You’ll start out as strangers and finish as lifelong friends.

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Ted’s background is unique in the fitness industry and includes the following highlights:

  • 20 years in sales and marketing with packaged goods companies (Quaker Oats / Best Foods)
  • One of the original founders of IRONMAN North America (launching IRONMAN races in the USA)
  • Hosted the first ever CEO IRONMAN Challenge in Lake Placid in 2001
  • Started CEO Challenges with an exclusive license deal from IRONMAN in 2005
  • Sold his company to $1.4 billion Life Time Fitness in 2012 with the agreement to run it for five years

Ted has been interviewed by most major business news and fitness publications for hisCEO Challenges knowledge and relationship with CEOs that have a passion for endurance events. The CEO Challenge database includes 1,900 opt-in subscribers who receive monthly newsletters with race results and announcing new CEO Challenge events around the world. CEO Challenges enjoys an 83% post-event rating of ‘exceeded’ or ‘far exceeded’ expectations from some of the world’s most discerning customers.


nfl-knee-injurySegment Two: Dr. Brian Cole discusses the prevalence and his experience with
cartilage and complex knee issues in professional athletes; new techniques in dealing with the long recovery times; load related activity & pain management.


Segment Three:  Captain Matthew T. Provencher, MD MC USN with the Steadman Philippon Research Institute and Head Team Physician with the New England Patriots during their 2014 Super Bowl Championship Season. Dr. Provencher talks with Steve and Dr. Cole about his work in research; NBA vs NFL injuries and experience in setting up the Navy Seal Special Forces Tactical Athlete program.

Matthew T. ProvencherDr. Provencher graduated in 1993 with highest honors from the United States Naval Academy and was the Secretary of the Navy Distinguished Graduate, where he was an all-American rower. He earned his medical degree with Honors from Dartmouth Medical School in 1998.

He has served as Chief of Sports Medicine at The Massachusetts General since April 2013 and has been with the Patriots for the last two seasons. He also serves as a Professor of Surgery and Orthopaedics at the Uniformed Services University of the Health Sciences (USUHS) and is a Visiting Professor at The Harvard Medical School.

Dr. Provencher completed his orthopaedic residency at the Naval Medical Center San Diego and his orthopaedic shoulder knee and sports surgery fellowship at Rush University in Chicago. A prolific researcher, he has received numerous academic and research awards including the American Orthopaedic Society for Sports Medicine (AOSSM) Aircast Award, The International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) Science Award.

He was also selected for several prestigious traveling fellowships, including the AOSSM Asia-Pacific, the American Orthopaedic Association (AOA) John Fahey North American Traveling Fellowship, and the American-British-Canadian (ABC) Fellowship. In addition, he has received multiple peer-reviewed research grants totaling over $1.5M to study topics such as shoulder instability, rotator cuff injuries, and ACL tears from funding agencies including, OREF, PRORP, and The Department of the Army and Navy.

Ankle Injuries; Bone Bruises; Men’s Health

Episode 16.33 with Hosts Steve Kashul and Dr. Brian Cole. Broadcasting on ESPN Chicago 1000 WMVP-AM Radio, Saturdays from 8:30 to 9:00 AM/c.

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Segment One: Dr. Simon Lee from Midwest Orthopaedics at Rush discusses sprains, dr-simon-leeachilles and other foot and ankle injuries; bracing vs taping. According to the American Academy of Orthopedic Surgeons (AAOS), 25 percent of all injuries from sports are to the foot and ankle. Athletes who play certain sports with sudden foot movements, such as hockey, basketball, football and tennis, are at a greater risk of ankle injuries. However, The Clinical Journal of Sports Medicine reports that the sports that cause the most ankle injuries are boys’ and girls’ basketball and girls’ gymnastics.

For dancers, the rate of ankle injuries is even higher than for those who play sports. A full 50 percent of dancers’ injuries are to the foot or ankle. Dancers’ feet and ankles endure twists, turns and heavy load during practices and performances. In addition, they are under pressure to stay thin and may eat too few nutrients, exacerbating injuries by weakening their bones and muscles. A minor injury to the ankle will leave athletes or dancers sidelined for at least two weeks. However, a major ankle injury, like a severe sprain or Achilles rupture, can take months to heal. If an athlete doesn’t allow enough time for recovery, they are at risk of sustaining a re-injury.

While there is a rising number foot and ankle injuries in athletes and dancers, researchAnkles for Life shows that these injuries can be prevented by performing ankle balance, stretching and strengthening exercises and alternating with another sport. This is why the Midwest Orthopedics at Rush (MOR) and the Illinois Athletic Trainers Association (IATA) have teamed up to promote awareness and prevention of ankle injuries.Ankles for Life aims to provide essential information regarding specific ankle injuries and tips for preventing these injuries in the future.


Segment Two: Steve and Dr. Cole discuss the recent bone bruise injury suffered by Michael Carter Williams of the Chicago Bulls. Definition, causes, diagnosis, treatment, recovery and decisions on when to return to play.

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Bulls guard Michael Carter-Williams will miss four to six weeks with a left knee bone bruise. Carter-Williams suffered the injury while taking a hard fall on defense. An MRI revealed no ligament damage in his knee, the team said.


Segment Three: Brett Wapotish from Athletico specializes in pelvic floor disorders in men and describes the causes, symtoms and treatment. Chances are you have heard the month of November referred to as Movember several times over the last few years. While the first thing that comes to mind is probably mustaches, it is important to know that there is a bigger cause behind the Movember movement.

movemberMovember brings awareness to common men’s health issues, such as cancer and heart disease, as well as highlights the benefits of living a healthy lifestyle. Athletico has supported the Movember movement for three years via our AthletiMo team, which anyone can join to help raise funds and spread the word about men’s health.

Learn more about how you can participate with the AthletiMo’s

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